Tranexamic Acid for Skin: Benefits, Side Effects & Uses

Tranexamic acid is a medication that has gained popularity in the skincare industry due to its potential benefits for the skin. Originally used to treat heavy bleeding, tranexamic acid has been found to be effective in reducing hyperpigmentation, melasma, and other skin discoloration issues. In addition, it has also been found to improve the overall appearance and texture of the skin, making it a popular ingredient in many skincare products. However, like any other skincare ingredient, tranexamic acid also has its side effects and potential risks that need to be considered. In this blog, we will explore the uses of tranexamic acid for the skin, its potential benefits and side effects, and how it works when combined with other skincare ingredients such as retinol and niacinamide.

5 Benefits of Tranexamic Acid on Skin

Tranexamic acid (TXA) provides several skin benefits, making it a versatile ingredient in skincare formulations. Here are five key benefits of applying tranexamic acid to the skin:

1. Reduces hyperpigmentation and melasma: Tranexamic acid has been found to be effective in reducing hyperpigmentation and melasma, which are common skin discoloration issues. It works by blocking the production of melanin, the pigment that gives colour to our skin and preventing its accumulation in the skin. Regular use of tranexamic acid has been shown to reduce the appearance of dark spots and uneven skin tone.

2. Brightens and evens out skin tone: Tranexamic acid has also been found to brighten and even out the skin tone, making it look more radiant and youthful. Its ability to reduce the production of melanin and prevent its accumulation in the skin helps to create a more even skin tone.

3. Improves skin texture: Tranexamic acid has been found to improve the overall texture of the skin by reducing inflammation and promoting collagen production. It helps to reduce the appearance of fine lines and wrinkles, making the skin look smoother and more supple.

4. Helps treat acne: Tranexamic acid has also been found to be effective in treating acne. Its ability to reduce inflammation and prevent the accumulation of melanin in the skin helps to reduce the appearance of acne scars and dark spots.

5. Moisturizes and hydrates the skin: Tranexamic acid has moisturizing and hydrating properties that help to keep the skin soft and supple. It works by enhancing the skin's natural moisture barrier and preventing water loss, which is important for maintaining healthy and youthful-looking skin.

Overall, tranexamic acid has several potential benefits for the skin, making it a popular ingredient in many skincare products. However, it's important to note that its effectiveness may vary depending on the individual and the specific skin concern being treated. It's always best to consult with a dermatologist or skincare professional before using any new skincare product or ingredient.

How to Use Tranexamic Acid for Skin

Tranexamic acid is available in various forms, including serums, creams, and lotions. When using tranexamic acid for the skin, it's important to follow the instructions on the product label carefully. Generally, it's recommended to use a small amount of the product on clean, dry skin twice a day, preferably in the morning and evening.

To apply tranexamic acid (TXA) to your skin, follow these instructions:

• Patch Test: Before incorporating any new TXA-containing skincare product into your routine, conduct a patch test. Apply a small amount of the product to a discreet area of your skin (such as the inner forearm) and wait 24-48 hours to see if any adverse reactions occur, such as redness, itching, or irritation.

• Choose the Right Product: Choose a skin care product enriched with TXA that is appropriate for your skin type and concerns. TXA can be found in a variety of products, including serums, creams, masks, and spot treatments.

• Cleanse Your Skin: Start with clean skin by washing your face with a gentle cleanser suited to your skin type. Pat your skin dry with a clean towel.

• Apply TXA Product: Apply a pea-sized amount of the TXA product to your fingertips or directly to the areas of concern. Gently massage the product into your skin in upward, circular motions until completely absorbed.

• Allow Absorption Time: Let the TXA product absorb into your skin before applying any other skincare products. This could take several minutes.

• Follow with Moisturizer (if needed): Depending on your skin type and the formulation of the TXA product, you may want to use a moisturiser to seal in hydration and nourish your skin.

• Use Sunscreen: If you use TXA during the day, apply a broad-spectrum sunscreen with SPF 30 or higher as the final step in your skincare routine. TXA may make your skin more sensitive to sunlight, so sunscreen protects your skin from harmful UV rays and prevents further hyperpigmentation.

• Consistency is Key: Incorporate TXA into your skincare routine consistently for best results. Use it as directed, once or twice a day, to see noticeable improvements in your skin's tone and texture over time.

• Monitor Results: Pay attention to how your skin responds to TXA. It may take several weeks to notice significant improvements in hyperpigmentation or other skin issues. If you experience irritation or adverse reactions, stop using the product and consult a dermatologist.

It's also important to note that tranexamic acid can make the skin more sensitive to the sun, so it's important to use a broad-spectrum sunscreen with an SPF of 30 or higher during the day.

Use Tranexamic Acid for Hyperpigmentation and Skin Whitening!

Tranexamic acid is an excellent ingredient that has demonstrated its effectiveness in reducing hyperpigmentation, improving skin tone, and enhancing overall skin health. It is a powerful tool in the fight against skin discoloration and has shown promising results in reducing dark spots, melasma, and other forms of hyperpigmentation. However, it is important to use Tranexamic acid products as directed and to be aware of potential side effects. As with any skincare ingredient, it is also important to choose well-formulated products that are suitable for your skin type and concerns. Additionally, combining Tranexamic acid with other beneficial ingredients such as retinol, niacinamide, or vitamin C can enhance its effects and further improve skin health. By incorporating Tranexamic acid into your daily skincare routine, you can achieve a brighter, more even complexion and improve the overall appearance and health of your skin. So, if you are struggling with hyperpigmentation or looking for an effective skin whitening solution, Tranexamic acid is definitely worth considering.

Using Tranexamic Acid and Retinol Together

Retinol is a popular anti-aging ingredient that can help improve the appearance of fine lines, wrinkles, and uneven skin tone. When used in combination with tranexamic acid, it can help enhance the benefits of both ingredients.

To use tranexamic acid and retinol together, start by using a small amount of retinol on clean, dry skin every other night. After a week or two, you can add tranexamic acid to your routine by using it in the morning and retinol in the evening.

It's important to note that both tranexamic acid and retinol can cause skin irritation, especially if used in high concentrations. Start by using a low concentration of each ingredient and gradually increase the concentration as your skin adjusts.

Using Tranexamic Acid and Niacinamide Together

Niacinamide is a vitamin B3 derivative that can help reduce inflammation and improve the overall appearance of the skin. When used in combination with tranexamic acid, it can help improve the skin's texture and reduce the appearance of hyperpigmentation.

To use tranexamic acid and niacinamide together, start by using a small amount of niacinamide on clean, dry skin in the morning. After a week or two, you can add tranexamic acid to your routine by using it in the evening.

Using Tranexamic Acid and Vitamin C Together

Vitamin C is a potent antioxidant that can help brighten the skin and reduce the appearance of dark spots and hyperpigmentation. When used in combination with tranexamic acid, it can help enhance the brightening and skin-evening effects of both ingredients.

To use tranexamic acid and vitamin C together, start by using a small amount of vitamin C on clean, dry skin in the morning. After a week or two, you can add tranexamic acid to your routine by using it in the evening.

It's important to note that vitamin C can be unstable and can degrade when exposed to light and air. Look for products that come in opaque or dark-coloured packaging and store them in a cool, dark place.

Side Effects of Tranexamic Acid on Skin

While Tranexamic acid is generally considered safe for use on the skin, some people may experience side effects. These side effects can vary from person to person and can depend on the concentration and formulation of the Tranexamic acid product used. Some of the most common side effects of Tranexamic acid on the skin include:

1. Skin Irritation - Tranexamic acid can cause skin irritation, redness, and itching, especially if you have sensitive skin or use a product with a high concentration of Tranexamic acid. If you experience any of these symptoms, it's best to discontinue the use of the product and consult with a dermatologist.

2. Sun Sensitivity - Tranexamic acid can make your skin more sensitive to the sun, increasing your risk of sunburn and skin damage. It's essential to use a broad-spectrum sunscreen with an SPF of 30 or higher when using Tranexamic acid products. Additionally, it's best to avoid direct sun exposure and wear protective clothing such as hats and long-sleeved shirts.

3. Dryness - Tranexamic acid can cause dryness and flakiness of the skin, especially if used in high concentrations or combined with other drying ingredients. It's important to maintain proper hydration levels by drinking plenty of water and using a moisturizer that suits your skin type. Avoid using products that contain alcohol, which can exacerbate dryness.

4. Acne - In rare cases, Tranexamic acid can worsen acne and cause breakouts, especially if used in high concentrations or combined with other pore-clogging ingredients. If you have acne-prone skin, it's best to consult with a dermatologist before using any Tranexamic acid products.

Overall, Tranexamic acid is a powerful ingredient that can provide many benefits for the skin, but it's essential to use it safely and correctly. Always start with a low concentration and patch test before applying it to your entire face. If you experience any adverse reactions, discontinue use immediately and consult with a dermatologist.

Optimizing Your Skincare Routine with Tranexamic Acid

Tranexamic acid (TXA) is a versatile ingredient that can address a variety of skin concerns, including hyperpigmentation and inflammatory conditions such as rosacea. When incorporating TXA into your skincare routine, consider the following tips to maximise the benefits:

• Understand Your Skin Needs: Identify your main skin concerns, such as hyperpigmentation, redness, or uneven skin tone. Tranexamic acid is an effective treatment for these issues.

• Choose the Right Products: Look for skincare products that contain an appropriate amount of TXA. These can be serums, creams, or spot treatments. To achieve the best results, make sure the product contains stable TXA concentrations.

• Patch Test: Before using TXA-containing products on your entire face, perform a patch test on a small area of skin to check for any adverse reactions or allergies.

• Consistency is Key: To achieve the best results, incorporate TXA into your daily skincare routine. Consistent use over time can effectively reduce hyperpigmentation and redness.

• Layering: Consider the order in which you use your skincare products. In general, use TXA-containing products after cleansing and toning, but before heavier creams or oils. This enables it to penetrate the skin effectively.

• Sun Protection: TXA can increase your skin's sensitivity to sunlight, so use sunscreen every day, even on cloudy days. Choose a broad-spectrum sunscreen with SPF 30 or higher to protect your skin from UV rays.

• Combine with Other Actives: TXA can be combined with other skincare ingredients such as niacinamide, vitamin C, or retinoids to increase its effectiveness. To avoid irritation or sensitivity, introduce new actives gradually.

• Be Patient: Results from skincare products, including those containing TXA, may take time to appear. It may take several weeks or months of consistent use to notice significant improvements in hyperpigmentation or redness.

• Consult a Dermatologist: If you have severe or persistent skin problems, or if you're unsure about incorporating TXA into your routine, see a dermatologist. They can offer personalised advice and suggest the best products for your skin type and concerns.

By following these tips, you can optimize your skincare routine with tranexamic acid and achieve clearer, more even-toned skin.

Incorporating Sun Protection

Sun protection is essential for maintaining healthy, youthful-looking skin, particularly when using skincare products containing active ingredients such as tranexamic acid (TXA). Here's how to successfully incorporate sun protection into your routine:

1. Use a Broad-Spectrum Sunscreen: Look for a sunscreen that protects your skin against both UVA and UVB rays. This protects against sunburn, premature ageing, and skin cancer.

2. Choose the Right SPF: Use a sunscreen with a Sun Protection Factor (SPF) of 30 or higher. This provides adequate UVB protection. However, if you have fair skin, a history of skin cancer, or spend long periods in the sun, use SPF 50 or higher.

3. Apply Sunscreen Daily: Sunscreen should be applied every morning as the final step in your skincare routine, after moisturizer and before makeup (if applicable). Even on cloudy days, UV rays can penetrate clouds and cause damage to your skin.

4. Reapply Throughout the Day: If you will be spending a long time outside, reapply sunscreen every two hours, or more frequently if you sweat or swim. This provides continuous protection against sun damage.

5. Consider Sunscreen Ingredients: Some sunscreen ingredients, like zinc oxide and titanium dioxide, offer physical (or mineral) protection by reflecting UV rays away from the skin. Chemical sunscreen ingredients such as avobenzone and octocrylene absorb ultraviolet radiation and convert it to heat. Choose the formulation that best suits your skin type and preferences.

6. Do not Forget Your Lips: Lips are frequently overlooked when it comes to sun protection. Use a lip balm or lipstick with SPF to shield your lips from the sun's harmful rays.

7. Protect Exposed Areas: Apply sunscreen to all exposed areas of your body, such as your neck, ears, hands, and any other areas not covered by clothing.

8. Combine with Protective Clothing: In addition to sunscreen, wearing protective clothing such as wide-brimmed hats, sunglasses, and long-sleeved shirts can help shield your skin from UV damage.

9. Avoid Peak Sun Hours: Whenever possible, limit your time outside between 10 a.m. and 4 p.m., when the sun's rays are at their most intense.

By incorporating these sun protection practices into your skincare routine, you can protect your skin from sun damage while also reaping the benefits of skincare products containing tranexamic acid and other active ingredients.

Hydration and Tranexamic Acid

Hydration is essential for healthy skin and plays an important role in maximising the benefits of skincare ingredients such as tranexamic acid. Here's how to maintain proper hydration while incorporating TXA into your skincare routine:

• Hydrating Cleanser: Begin your skincare routine with a gentle, hydrating cleanser that removes impurities while leaving the skin moisturised. Look for formulas that include ingredients like hyaluronic acid or glycerin to help replenish hydration levels.

• Moisturise: After cleansing, use a hydrating moisturiser on your skin. Look for moisturisers containing ingredients like hyaluronic acid, ceramides, or squalane, which help to attract and retain moisture, leaving your skin soft and supple.

• Layer TXA Products: After moisturising, use skincare products containing tranexamic acid, such as serums or creams, to address specific skin concerns like hyperpigmentation or redness. Layering TXA on moisturised skin can help increase its efficacy while keeping it hydrated.

• Hydrating TXA Formulations: To avoid dryness or irritation, look for TXA-containing products that include hydrating ingredients. This keeps your skin hydrated while providing the benefits of TXA.

• Hyaluronic Acid Boost: To increase hydration, consider using a hyaluronic acid serum or essence in your skincare routine. Hyaluronic acid is a humectant that attracts and retains moisture, plumping and hydrating the skin.

• Facial Mists: Keep a facial mist on hand throughout the day to give your skin an instant hydration boost whenever it feels dry or tight. Choose a mist containing hydrating ingredients such as rosewater or aloe vera.

• Drink Plenty of Water: Hydration is more than just what you put on your skin; it also includes what you put in your body. Drink plenty of water all day to keep your skin hydrated from the inside out.

• Humidifier: Consider using a humidifier in your home, especially during the winter months when indoor heating can deplete the air. A humidifier maintains optimal moisture levels in the air, preventing skin dehydration. 

• Protective Barrier: As the final step in your skincare routine, apply a thin layer of occlusive moisturiser or facial oil to lock in moisture and protect your skin's natural barrier. This reduces moisture loss and keeps your skin hydrated all day or night.

By focusing on hydration and incorporating TXA-containing products into your skincare routine, you can effectively address skin concerns while maintaining a healthy, hydrated complexion.

Combining Tranexamic Acid with Other Skincare Acids

Combining tranexamic acid (TXA) with other skincare acids can help address a variety of skin concerns, but it must be done carefully and with patch testing to avoid irritation or over-exfoliation. Here's how you can safely incorporate TXA and other skincare acids:

1. Before combining TXA with other acids, run a patch test on a small area of your skin to see how it reacts. This helps determine if your skin can tolerate the combination without irritation.

2. Introduce one new acid at a time to your skincare routine, gradually increasing the frequency or concentration as tolerated. This allows your skin to adjust while reducing the risk of irritation.

3. Some acids require a specific pH level to function. Check the pH of your TXA-containing products and other acids to make sure they are compatible and can work together effectively.

4. To avoid over-exfoliation and irritation, alternate between acids or use them at different times of day. For example, use TXA in the morning and another acid in the evening, or alternate days between acids.

5. To reduce the risk of irritation, combine acids at lower concentrations. You can gradually increase the concentration as your skin becomes tolerant.

6. Pay close attention to how your skin reacts to the acidic combination. If you notice any redness, stinging, or excessive dryness, reduce or discontinue use temporarily until your skin calms down.

7. Incorporate hydrating ingredients such as hyaluronic acid, glycerin, or ceramides into your skincare routine to help keep your skin barrier hydrated. Hydration helps to reduce the potential irritation caused by acids.

8. Acids, including TXA, can make skin more sensitive to sunlight. Wear sunscreen every day, even on cloudy days, to protect your skin from UV damage and reduce the risk of post-inflammatory hyperpigmentation.

9. If you are unsure about combining TXA with other acids, or if you have sensitive or reactive skin, speak with a dermatologist for personalised advice and recommendations based on your skin type and concerns.

By following these guidelines and paying attention to your skin's needs, you can safely combine TXA with other skincare acids to effectively address multiple skin concerns while reducing the risk of irritation or over-exfoliation.

Advanced Tips for Tranexamic Acid Use

If you want to maximise the benefits of tranexamic acid (TXA) in your skincare routine, consider these advanced tips:

• TXA can be combined with other active ingredients to increase its effectiveness. Consider combining it with niacinamide, vitamin C, or retinoids to address a variety of skin concerns, including hyperpigmentation, inflammation, and ageing. However, begin slowly and patch test to ensure compatibility and reduce the risk of irritation. 

• If you can not find a commercial skincare product containing TXA that works for you, talk to a dermatologist or compounding chemist about creating a customised formulation based on your skin concerns and preferences.

• In addition to topical skincare products, dermatologists and estheticians can use TXA in professional treatments. TXA-infused chemical peels, micro-needling with TXA serums, and laser treatments with TXA are all options for treating stubborn hyperpigmentation or melasma.

• Consider using TXA as a spot treatment for hyperpigmentation or redness. To address specific concerns without overtreating the surrounding skin, apply a small amount of TXA serum directly to the affected areas using a cotton swab or precision applicator.

• To improve TXA absorption and efficacy, experiment with various layering techniques. For example, after cleansing and toning, use a hydrating essence or serum to prepare the skin, then a TXA serum or cream, and finally a moisturiser to lock in the active ingredients.

• Some skincare experts recommend leaving TXA-containing products on the skin for an extended period, such as overnight, to ensure maximum absorption and efficacy. This can be especially useful for treating stubborn hyperpigmentation or melasma.

• Consider combining topical TXA with oral tranexamic acid supplements for enhanced results, especially in cases of severe hyperpigmentation or melasma. However, consult with a healthcare professional before incorporating oral supplements into your skincare regimen to ensure safety and efficacy.

• Keep track of your skin's progress and adjust your skincare routine as needed. It may take several weeks or even months to see significant improvements in hyperpigmentation or other skin concerns, so be patient and consistent with your TXA use.

• Always prioritize sun protection when using TXA, as it can increase skin sensitivity to sunlight. Apply a broad-spectrum sunscreen with SPF 30 or higher daily and reapply as needed, especially when spending extended time outdoors.

By incorporating these advanced tips into your skincare routine, you can optimize the benefits of tranexamic acid and achieve clearer, more even-toned skin. However, remember to listen to your skin and adjust your routine accordingly to maintain its health and balance.

Layering Skincare Products with Tranexamic Acid

To ensure maximum absorption and efficacy, layer skincare products containing tranexamic acid (TXA) in a specific order. Here's a step-by-step guide to layering skincare products using TXA:

1. Cleanse: Begin by cleansing your skin to remove any dirt, oil, or makeup. Choose a gentle cleanser suitable for your skin type to avoid stripping away essential moisture.

2. Tone (Optional): If you use a toner in your skincare routine, apply it after cleansing to balance the skin's pH levels and prepare it for the next steps. Look for alcohol-free toners with hydrating or soothing ingredients to support skin health.

3. Exfoliation (Optional): If you use exfoliating acids like AHAs (alpha hydroxy acids) or BHAs (beta hydroxy acids) in your routine, do so after cleansing and toning (if applicable). However, exercise caution when using exfoliating acids in conjunction with TXA to avoid overexfoliation and irritation.

4. Tranexamic Acid (TXA): Use your TXA-containing product as the next step in your routine. This allows TXA to effectively penetrate the skin and address issues like hyperpigmentation, redness, and inflammation. Use the recommended amount and gently massage it into the skin until fully absorbed.

5. Serums: If you use any other serums in your routine, apply them after TXA. Serums with lightweight textures and targeted ingredients can address specific skin concerns like hydration, brightening, and anti-aging.

6. Moisturizer: Apply a moisturiser to seal in hydration and form a protective barrier on the skin's surface. Look for a moisturiser that is appropriate for your skin type, whether it is lightweight for oily or combination skin or rich for dry skin.

7. Eye Cream: To hydrate and protect the delicate skin around the eyes, apply an eye cream after your moisturiser. Choose an eye cream formulated with gentle ingredients to address concerns like dark circles, puffiness, or fine lines.

8. Sunscreen: After your morning skincare routine, apply a broad-spectrum sunscreen with SPF 30 or higher. Apply sunscreen liberally to all exposed areas of your face and neck, even on cloudy days, to protect your skin from UV damage and prevent future hyperpigmentation.

9. Nighttime Routine (Optional): If you have an evening skincare routine, you can skip the sunscreen and instead use retinoids, peptides, or hydrating masks to address specific nighttime skincare concerns.

By following this layering sequence, you can ensure that TXA penetrates the skin effectively and works in conjunction with other skincare products to address your specific skin concerns. Additionally, remember to patch-test new products and gradually incorporate them into your routine to reduce the risk of irritation or adverse reactions.

Nighttime vs. Daytime Use

The decision to use tranexamic acid (TXA) in your skincare routine during the day or at night is based on several factors, including your skin's sensitivity, the concentration of TXA in your products, and your specific skin concerns. Below is a breakdown of the considerations for both daytime and nighttime use:

Daytime Use:

• TXA may make skin more sensitive to sunlight, increasing the risk of sunburn and damage. If you choose to use TXA during the daytime, ensure that you apply a broad-spectrum sunscreen with SPF 30 or higher as the final step in your skincare routine to protect your skin from UV radiation.

• Daytime use of TXA can be beneficial for addressing hyperpigmentation, sunspots, and melasma, as these conditions often worsen with sun exposure. TXA helps inhibit melanin production, reducing the appearance of dark spots and promoting a more even skin tone.

• TXA-containing products can be layered under makeup during the daytime. However, allow sufficient time for the TXA product to absorb into the skin before applying makeup to ensure optimal efficacy.

Nighttime Use:

1. Since TXA can increase sun sensitivity, nighttime use may be preferred for individuals who are concerned about sun exposure or spend minimal time outdoors during the day. Using TXA at night reduces the risk of UV-related skin damage.

2. Nighttime is an ideal time to incorporate TXA into your skincare routine because the skin undergoes repair and regeneration processes while you sleep. TXA can work alongside other reparative ingredients to promote skin renewal and fade hyperpigmentation more effectively.

3. If you're using other active ingredients like retinoids or exfoliating acids in your nighttime routine, TXA can be seamlessly integrated to target multiple skin concerns such as fine lines, acne scars, and uneven skin tone.

4. The absence of sunlight during the nighttime allows for better penetration and absorption of TXA into the skin, maximizing its efficacy in addressing hyperpigmentation and other skin concerns.

Maximizing the Efficacy of Tranexamic Acid in Your Skincare Regimen

To optimise the efficacy of tranexamic acid (TXA) in your skincare regimen, consider the following tips:

• Choose skincare products with stable and effective TXA concentrations. Look for reputable brands with a history of producing high-quality formulations.

• TXA is effective at treating a variety of skin issues, including hyperpigmentation, melasma, redness, and inflammation. Identify your primary skin concerns so that your skincare routine can be tailored accordingly. 

• Include TXA-containing products in your daily skincare routine and use them consistently. Consistent use over time is required to see visible improvements in your skin's appearance.

• TXA products should be applied according to the manufacturer's instructions. This could include using the product once or twice a day, applying it to clean, dry skin, and allowing it to fully absorb before applying additional skincare products.

• TXA can make skin more sensitive to sunlight, so use a broad-spectrum sunscreen with SPF 30 or higher every day, even on cloudy days. Sunscreen protects your skin from UV damage and slows the progression of hyperpigmentation.

• TXA can be combined with other skincare actives to increase its effectiveness. Consider combining TXA with vitamin C, niacinamide, or retinoids to address multiple skin concerns at once. However, gradually introduce new actives to reduce the risk of irritation.

• Results from skincare products, including those containing TXA, may take time to appear. It may take several weeks or even months of consistent use to notice significant improvements in hyperpigmentation, melasma, and other skin issues. Be patient and stick to your skincare routine.

• In addition to topical skincare products, consider professional treatments like chemical peels, microdermabrasion, or laser therapy to supplement your TXA skincare routine. These treatments can help you see faster results and address stubborn skin issues.

• If you have severe or persistent skin problems, or if you are unsure about incorporating TXA into your skincare routine, see a dermatologist. They can offer tailored recommendations and advice based on your skin type, concerns, and medical history.

By following these guidelines and effectively incorporating TXA into your skincare routine, you can increase its efficacy and achieve clearer, more even-toned skin over time.